- The Good German (2006) (announced) .... Jake Geismar
- Syriana (2005) (post-production) .... Robert Baer
- Goodnight, and Good Luck (2005) (post-production) .... Fred Friendly
- Ocean's Twelve (2004) .... Danny Ocean
- Intolerable Cruelty (2003) .... Miles Massey
- Spy Kids 3-D: Game Over (2003) .... Devlin
... aka Spy Kids 3: Game Over (USA: video title) - Confessions of a Dangerous Mind (2002) .... Jim Byrd
... aka Confessions d'un homme dangereux (Canada: French title) - Solaris (2002) .... Chris Kelvin
- Welcome to Collinwood (2002) .... Jerzy
... aka Safecrackers oder Diebe haben's schwer (Germany) - Ocean's Eleven (2001) .... Danny Ocean
... aka 11 (USA: promotional abbreviation) ... aka O11 (USA: informal short title) - Spy Kids (2001) .... Devlin
- The Perfect Storm (2000) .... Capt. Billy Tyne
... aka Sturm, Der (Germany) - O Brother, Where Art Thou? (2000) .... Everett
... aka O' Brother (France) - Fail Safe (2000) (TV) .... Col. Jack Grady (command pilot, Group 6)
- Three Kings (1999) .... Maj. Archie Gates
- South Park: Bigger Longer & Uncut (1999) (voice) .... Dr. Gouache/Dr. Doctor
... aka South Park: Bigger, Longer & Uncut (USA: closing credits title) - The Thin Red Line (1998) .... Captain Charles Bosche
... aka Mince ligne rouge, La (Canada: French title) - Out of Sight (1998) .... Jack Foley
- The Peacemaker (1997) .... Lt. Col. Thomas Devoe
- Batman & Robin (1997) .... Batman/Bruce Wayne
- One Fine Day (1996) .... Jack Taylor
- Curdled (1996) (uncredited) .... Seth Gecko
- From Dusk Till Dawn (1996) .... Seth Gecko
- "ER" (1994) TV Series .... Dr. Douglas Ross (1994-1999)
- ER (1994) (TV) .... Dr. Douglas 'Doug' Ross
- "Sisters" (1991) TV Series .... Detective James Falconer (1993-1994)
- The Harvest (1993) .... Lip Syncing Transvestite
- Without Warning: Terror in the Towers (1993) (TV) .... Kevin Shea
- "Bodies of Evidence" (1992) TV Series .... Det. Ryan Walker (1992-1993)
- Unbecoming Age (1992) .... Mac
... aka The Magic Bubble - "Baby Talk" (1991) TV Series .... Joe (1991)
- Rewrite for Murder (1991) (TV)
- "Sunset Beat" (1990) TV Series .... Chic Chesbro
- Sunset Beat (1990) (TV) .... Chic Chesbro
- Knights of the Kitchen Table (1990) (TV) .... Rick Stepjack
- Red Surf (1990) .... Remar
- Return of the Killer Tomatoes! (1988) .... Matt Stevens
... aka Return of the Killer Tomatoes: The Sequel (USA: video box title) - Return to Horror High (1987) .... Oliver
- Grizzly II: The Predator (1987)
- Combat High (1986) (TV) .... Maj. Biff Woods
... aka Combat Academy - "The Facts of Life" (1979) TV Series .... George Burnett (1985-1986)
- "E/R" (1984) TV Series .... Ace (1984-1985)
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