Reeser is perhaps best-known for her character Taylor Townsend on popular television series, The O.C.. She first appeared during the third season and joined as a regular cast member the following season. In addition to The O.C., Reeser has appeared on numerous television shows including HBO's Entourage, WB's Maybe It's Me, ABC's Complete Savages, WB's Grounded for Life, FX Network's It's Always Sunny in Philadelphia, ABC's Pushing Daisies, Fox's Human Target, CBS's Ghost Whisperer, TNT's Raising the Bar, The CW pilot The World According to Barnes, and the ABC Family's October film Nature of the Beast. Additionally, Reeser played the starring role of Phoebe Valentine, Goddess of the Oracle at Delphi, in the CW Network series Valentine. Reeser also appeared in the ABC television series No Ordinary Family during the 2010-11 season. She has also appeared in a number of films including the 2008 sequel of a 1980s cult classic, Lost Boys: The Tribe, Smokin' Aces 2: Assassins' Ball, The Girl Next Door, and a movie musical by the High School Musical producers, called "The American Mall."
Reeser has also appeared in Internet projects, including four YouTube trailers for the novel Celebutantes as the book's narrator Lola Santisi and as a guest-star on The Bannen Way, a serial action show created by her husband, Jesse Warren.
She portrayed Commander Lissette Hanley in Electronic Arts's 2008 video game Command & Conquer: Red Alert 3.
Maxim ranked Reeser as the 57th most beautiful woman in the world in 2006. She also appeared on the cover of the December 2006 issue of Stuff magazine (U.S. version)
Reeser is a spokesperson for Clean & Clear.
Reeser appears regularly in The Thrilling Adventure Hour, a staged show in the style of old-time radio. She is the star of the segment Amelia Earhart: Fearless Flyer.
In the fall of 2010 she starred in the concert revue For The Record: Quentin Tarantino in Los Angeles, presented by ROCKLA for Show at Barre. It ran from August 12, 2010, to October 30, 2010. Also starring Jenna Leigh Green, Tracie Thoms, Ty Taylor, Von Smith and Audra Mae.
Reeser also contributed to the 2008 video game Command & Conquer: Red Alert 3, voicing Commander Lissette Hanley of the Allied Nations. Her character also appears in the demo.